Research

Our overall aim is to understand the underlying mechanisms of neural development, the signal transduction events that occur during synaptic transmission, and the molecular bases of behavior. Our group is divided along two major fields of study.

Outline of Projects

The signal transduction pathways that are stimulated during synaptic transmission play critical roles in brain functions and are disrupted in various neural diseases. We are studying the expression and functions of glutamate receptors, the major receptors involved in excitatory neurotransmission. In particular, we are studying the signal transduction pathways stimulated specifically by glutamate receptor activation. In one project, we are studying how calcium influx through glutamate receptors leads to alterations in localization of some calcium binding protein and subsequent activation of transcription factors. Through these studies, we hope to understand the regulation of synaptic function and the molecular mechanisms involved in brain function.

Subcellular Localization of GluR2 subunits transfected into rat cultured neurons using an adenovirus vector. Intracellular GluR2 is shown in green and surface GluR2 in red.

Staff